论文部分内容阅读
用荧光组化法测定33例喉鳞癌及癌旁组织的睾丸酮、孕酮和雌二醇受体。3个受体在癌旁的表达为表面柱状上皮强于鳞状上皮,腺管上皮强于腺泡。在33例喉鳞癌中3个受体的阳性检出率分别为65％、43％和21％;显示喉鳞癌更依赖于睾丸酮。有48％的病例3个受体在同一病例表达一致,52％不一致;另1例伴淋巴结转移癌,其受体表达也与原发癌不一致;从受体角度显示部分病例癌细胞具异质性。受体的表达强度与组织分化有关,在良性鳞状上皮强于恶性,在高分化癌强于低分化癌。
The testosterone, progesterone and estradiol receptors in 33 cases of laryngeal squamous cell carcinoma and paracancerous tissues were measured by fluorescence histochemistry. The expression of the three receptors adjacent to the tumor was that the surface columnar epithelium was stronger than the squamous epithelium, and the glandular epithelium was stronger than the acinus. The positive detection rate of 3 receptors in 33 cases of laryngeal squamous cell carcinoma were 65%, 43% and 21%, respectively, indicating that laryngeal squamous cell carcinoma is more dependent on testosterone. In 48% of cases, 3 receptors were identical in the same case, 52% were inconsistent; in 1 case with lymph node metastases, the receptor expression was also inconsistent with the primary cancer; from the perspective of the receptor, some cases showed that the cancer cells were heterogeneous Sex. The intensity of receptor expression is related to tissue differentiation, benign squamous epithelium is stronger than malignant, and well differentiated carcinoma is stronger than poorly differentiated carcinoma.