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本文将10％的乙酸溶液2ml注入SD大白鼠的结肠,制作成溃疡性结肠炎模型,然后,肉眼及显微镜下观察预防给予SOD对结肠粘膜的保护作用。结果表明从静脉预防注入1万USOD组,第3日10只鼠结肠粘膜中呈正常或轻度充血7只,粘膜粗糙2只,重度炎症1只,生理盐水对照组10只鼠均表现为重度炎症。两组间比较有显著性差别(P<0.05)。第3周SOD组5只鼠,正常或轻度充血4只,1只呈细索状,硬度增加,发生肠粘连和狭窄,对照组5贝,1只因肠梗阻死亡,余4只呈不同程度的肠粘连和狭窄,硬度增加,两组比较有显著性
In this paper, 2 ml of 10% acetic acid solution was injected into the colon of SD rats to make a model of ulcerative colitis. Then, macroscopic and microscopic observation was performed to prevent the protective effect of SOD on colonic mucosa. The results showed that from the intravenous prophylaxis injection of 10 000 USOD group, on the 3rd of 10 mice colonic mucosa showed normal or mild congestion 7, mucosal rough 2, severe inflammation in 1, 10 saline control group showed severe Inflammation. There was a significant difference between the two groups (P <0.05). In the third week, 5 rats in SOD group, 4 rats in normal or mild hyperemia, 1 in cord-like shape, increased hardness and intestinal adhesion and stenosis. In control group, 5 rats died in 1 case due to intestinal obstruction and the other 4 rats were different Degree of intestinal adhesion and stenosis, increased hardness, the two groups were more significant