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本世纪初开始采用影响肾功能的实验方法引起动物产生高血压,如X射线照射肾,切除部分肾组织,阻塞肾动脉的主干或分支,缩小动脉静脉口径等,造成肾源性高血压。直到1934年戈德布拉特(Goldblatt)报导狭窄狗的肾动脉口径,又切除对侧肾后,形成持久性的动脉血压升高和心脏肥大。但是采用同样的实验方法狭窄脾动脉或股动脉则无血压升高
At the beginning of this century, experimental methods affecting renal function were used to induce hypertension in animals, such as X-ray irradiation of the kidney, removal of part of the kidney tissue, blockage of the trunk or branches of the renal artery, and reduction of arterial venous caliber, resulting in nephrogenic hypertension. Until 1934, Goldblatt reported a renal artery stenosis in a stenotic dog with the removal of the contralateral kidney, resulting in persistent arterial hypertension and cardiac hypertrophy. However, the use of the same experimental method for stenosis of the splenic artery or femoral artery results in no increase in blood pressure