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普罗帕酮(Propafenone)具有IC类抗心律失常药作用,兼有β受体阻滞剂和钙通道阻滞剂作用特点。临床前研究本品对由氯化钙或左冠脉阻塞引起的心律失常有治疗效果。Karagueuzian等证明,前壁心肌梗塞狗静注普罗帕酮4mg/kg,室速迅速被控制。与利多卡因不同的是,本品明显增加房室结功能性不应期和右室舒张期应激性,并使室內传导明显延长;但本品和利多卡因均不减慢希司-浦顷野系统传导。药动学本品口服95％以上吸收,2～3
Propafenone possesses IC anti-arrhythmic drug effect, which combines the functions of β-blocker and calcium channel blocker. Preclinical study of this product by the calcium chloride or left coronary artery obstruction caused by arrhythmia have a therapeutic effect. Karagueuzian et al. Demonstrated that dogs with anterior myocardial infarction were intravenously administered propafenone 4 mg / kg and VT was rapidly controlled. The difference is that with lidocaine, this product significantly increased functional ventricular tachycardia and right ventricular diastolic stress, and significantly prolonged indoor conduction; but this product and lidocaine do not slow down Hisilicon - Po is wild system conduction. Pharmacokinetics This product is more than 95% oral absorption, 2 to 3