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为了探索病毒性肝炎患者肝动脉血流动力学改变状况及其意义,本文采用彩色多普勒超声显像仪,检测急性肝炎(AH)、慢性肝炎(CH)和肝炎后肝硬化(LC)共67例患者的肝动脉血流的高峰流速(PS)、血流阻抗指数(RI)和时间平均流速(TAV)等,并与其肝功能、血浆游离氨基酸谱等作相关性研究。结果发现,LC组患者肝动脉的PS值显著低于AH组(P<001)和轻度慢性肝炎组(P<005),而胆红素升高组(TBi>171μmol/L)的PS值显著低于胆红素正常组(P<005);患者的肝动脉PS值与其血浆支链氨基酸/芳香族氨基酸的比值(BCAA/AAA)成正相关(P<005),而与其病变程度呈负相关(P<001)。由此可见:在病毒性肝炎时,随着病程的迁延及/或病变加重,患者的肝动脉血供将会出现不同程度的降低,而此种降低会影响肝脏的代谢功能,因此,在慢性肝炎及肝硬化的治疗中,应注意扩张肝动脉,改善肝血供,以保证肝的氧供给,有利于肝脏病变的恢复。
In order to explore the hepatic artery hemodynamic changes in patients with viral hepatitis and its significance, this paper uses color Doppler ultrasound imaging system to detect acute hepatitis (AH), chronic hepatitis (CH) and post-hepatitis cirrhosis (LC) The peak flow velocity (PS), RI and TAV of hepatic artery in 67 patients were studied, and their correlations with liver function and plasma free amino acid were studied. The results showed that the PS value of hepatic artery in LC group was significantly lower than that in AH group (P <001) and mild chronic hepatitis group (P <005), while the elevated bilirubin group (TBi> 171 μmol / L) was significantly lower than that of the normal bilirubin group (P <005). The PS value of the hepatic artery was positively correlated with the BCAA / AAA ratio (P <0 05), but negatively correlated with the degree of lesion (P <001). Thus, in the process of viral hepatitis, hepatic arterial blood supply will decrease to varying degrees as the course of the disease progresses and / or the lesion increases, and such reduction will affect the liver’s metabolic function. Therefore, in the chronic Hepatitis and cirrhosis treatment, should pay attention to the expansion of the hepatic artery, improve liver blood supply, in order to ensure the oxygen supply to the liver, is conducive to the recovery of liver disease.