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目的探讨普贝生(propess)用于足月妊娠引产的有效性和安全性。方法将100例初产妇随机分两组,每组50例。A组阴道内放置普贝生1枚,B组阴道内放置安慰剂作为对照。比较两组用药后宫颈Bishop评分、用药到临产发动时间、总产程、产后出血量、剖宫产率、胎儿宫内窘迫及新生儿窒息率。结果 A组用药12h的有效率(宫颈评分提高≥2分)明显高于B组(92%vs.12%)(P<0.05),用药到临产发动时间[(19.2±2.5)h vs.(52.3±3.2)h]、总产程时间[(8.6±2.1)hvs.(14.3±4.6)h]亦明显短于对B组(P<0.05),阴道分娩率增加(84%vs.52%),剖宫产率降低(16%vs.48%)。两组产后出血量、胎儿宫内窘迫及新生儿窒息率无统计学差异。结论普贝生能有效促进宫颈成熟,可安全用于引产。
Objective To investigate the efficacy and safety of propess in term pregnancy induced labor. Methods 100 primipara were randomly divided into two groups, 50 cases in each group. A group was placed Pessary 1 vagina, placebo vaginal B group as a control. The Bishop cervical score, medication time to delivery, total labor, postpartum hemorrhage, cesarean section rate, fetal distress and neonatal asphyxia were compared between the two groups. Results The effective rate (≥2 points) in group A was significantly higher than that in group B (92% vs. 12%) at 12 hours (P <0.05), and the time from labor to labor onset was (19.2 ± 2.5) h vs. ( 52.3 ± 3.2) h], and the duration of labor ([8.6 ± 2.1] hvs. (14.3 ± 4.6) h] was significantly shorter than that of group B (84% vs.52% , Cesarean section rate decreased (16% vs.48%). There was no significant difference in postpartum hemorrhage, fetal distress and neonatal asphyxia between the two groups. Conclusion Pu Bei Sheng can effectively promote the cervical ripening, can be safely used for induction of labor.