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目的观察盐酸米诺环素缓释剂局部用药辅助治疗老年中重度慢性牙周炎的临床疗效。方法将60例老年慢性牙周炎患者随机分为对照组和观察组各30例,对照组用20 g/L碘甘油治疗,观察组用2%盐酸米诺环素缓释剂治疗,观察两组用药前及用药4周末患者牙周袋探诊深度(PD)、牙龈指数(GI)变化,比较两组疗效。结果用药4周末观察组疗效优于对照组,两组比较差异有统计学意义(P<0.05);两组治疗后GI、PD均较治疗前改善,且观察组改善程度显著优于对照组(P<0.05)。结论盐酸米诺环素缓释剂辅助治疗老年慢性牙周炎疗效显著,可有效改善患者牙周炎症状,且疗效优于碘甘油组。
Objective To observe the clinical effect of local administration of minocycline hydrochloride sustained-release agent on middle-aged and severe chronic periodontitis. Methods Sixty elderly patients with chronic periodontitis were randomly divided into control group and observation group, 30 cases in each group. The control group was treated with 20 g / L iodine glycerol. The observation group was treated with 2% minocycline hydrochloride. Before treatment and at the end of 4 weeks, the patients’ PD probing depth (PD) and gingival index (GI) were compared. The curative effect was compared between the two groups. Results After 4 weeks of treatment, the observation group had better curative effect than the control group (P <0.05). GI and PD in both groups were better than those before treatment, and the improvement in the observation group was significantly better than that in the control group P <0.05). Conclusion Minocycline hydrochloride sustained-release adjuvant is effective in treating elderly patients with chronic periodontitis and can effectively improve the symptoms of periodontitis in patients, and its efficacy is better than that of iodine glycerin group.