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目前国外已开始将人癌移植于裸鼠筛选抗肿瘤药物,并提出正常动物组织类脂质的抗氧活性可用于抗肿瘤筛选。体外初筛,包括诱导肿瘤细胞逆向转化的方法,也受到广泛注意。目前已采用各种方法使微生物产生新的发酵产物,合成药物方面结构改造的目标也更为明确,并开始采用定量构效关系来进行药物设计。关于药物的设计已提出了多种途径,包括促进癌细胞分化、控制基因调控、将药物结合于抗肿瘤抗体或植物凝集素、刺激对外部转化敏感的蛋白合成、抑制表皮生长因子、阻止肿瘤血管生长因子的合成、抑制特异性蛋白酶、利用癌对特殊底物的要求,以及抑制逆转录酶活性等。
At present, foreign countries have begun to transplanted human cancer in nude mice screening anti-tumor drugs, and proposed normal animal tissue lipid antioxidant activity can be used for anti-tumor screening. In vitro screening, including the method of inducing the reverse transformation of tumor cells, is also receiving widespread attention. At present, various methods have been adopted to make microorganisms produce new fermentation products, and the goal of structural transformation of synthetic drugs is also more clear. Quantitative structure-activity relationships have also been used to design drugs. A number of approaches have been proposed with respect to drug design, including promoting cancer cell differentiation, controlling gene regulation, binding drugs to anti-tumor or lectins, stimulating protein synthesis sensitive to external transformation, inhibiting epidermal growth factor, preventing tumor blood vessels The synthesis of growth factors, the inhibition of specific proteases, the utilization of cancer for specific substrates, and the inhibition of reverse transcriptase activity.