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严重左室衰竭的患者一般均有心排出量下降及肺循环、体循环静脉压升高。主要作用于静脉容量血管的血管扩张剂可使左、右心室的充盈压降低;而主要作用于动脉阻力血管的扩张剂将使左室喷血阻抗降低,从而增加心排出量。许多研究证明对急性心肌梗塞或慢性心力衰竭患者静脉应用硝普钠、硝酸甘油、酚妥拉明等血管扩张剂,不但能降低肺循环和体循环静脉压,泵功能亦随之改善。鉴于长期静脉给药不切临床实用,须要寻找非注射用的血管扩张剂。本文系在慢性心力
Patients with severe left ventricular failure generally have decreased cardiac output and pulmonary circulation, systemic venous pressure. Vasodilators, which act primarily on the vessels of the venous volume, lower the filling pressure in the left and right ventricles; dilators, which act primarily on arterial resistance vessels, lower left ventricular ejection fraction and thus increase cardiac output. Many studies have shown that intravenous application of sodium nitroprusside, nitroglycerin, phentolamine and other vasodilators in patients with acute myocardial infarction or chronic heart failure can not only reduce the pulmonary circulation and systemic venous pressure, pump function also will be improved. Given the long-term intravenous administration is not cutting-edge clinical utility, need to find non-injectable vasodilators. This article is in the chronic heart