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目的探讨东莨菪碱抢救急性重度杀虫双中毒(ASBP)的治疗效果。方法 60例ASBP患者分为2组,对照组(30例)应用以二巯丙磺钠为主的综合治疗,治疗组(30例)应用以东莨菪碱为主的综合治疗。动态观测2组患者高铁血红蛋白水平、血清肌钙蛋白Ⅰ(cTnⅠ)和肌酸激酶同工酶(CK-MB)、肝肾功能和心电图等指标。结果治疗组平均病情好转时间为(6.85±0.55)h,明显短于对照组的(9.26±2.34)h(P<0.001),治疗组治疗后高铁血红蛋白水平、cTnⅠ、CK-MB水平、心电图、肝功能异常率等明显低于对照组(P<0.05、P<0.01或P<0.001)。结论东莨菪碱对ASBP有独到疗效,对中毒者心、脑、肝等重要器官有保护作用。
Objective To investigate the therapeutic effect of scopolamine on acute severe insecticidal double poisoning (ASBP). Methods Sixty patients with ASBP were divided into two groups. The control group (30 cases) was treated with sodium dimercaptopropanate. The treatment group (30 cases) was treated with combination of scopolamine. The levels of methemoglobin, serum cTnI and CK-MB, liver and kidney function and electrocardiogram in the two groups were observed dynamically. Results The mean time to improvement in the treatment group was (6.85 ± 0.55) h, which was significantly shorter than that in the control group (9.26 ± 2.34) h (P <0.001). The levels of methemoglobin, cTnⅠ, CK- Liver dysfunction rate was significantly lower than the control group (P <0.05, P <0.01 or P <0.001). Conclusion Scopolamine has a unique curative effect on ASBP and has a protective effect on important organs such as heart, brain and liver in poisoned patients.