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目的:探讨心力衰竭患者血浆脑钠肽(BNP)水平与心力衰竭严重程度、左室功能等因素的相关性。方法:将161例入选者分为正常对照组(42例)与HF组(119例),采用放射免疫法测定各组患者血浆BNP水平;使用心脏彩色多普勒超声诊断仪测定并比较各组左室射血分数(LVEF)、左心室舒张末期横径(LVEDd)。结果:心力衰竭患者BNP水平显著高于对照组(P<0.01),且BNP水平随着心功能NYHA分级的增加而显著增高,心力衰竭各组间BNP水平、LVEF、LVEDd差异均有统计学意义(P<0.05～0.01)。BNP水平与LVEF呈负相关(r=-0.685,P<0.001),而与LVEDd呈正相关(r=0.624,P<0.001)。结论:心力衰竭患者血浆BNP水平随着心力衰竭严重程度的增加而升高,并能较好的反映左室功能状态。
Objective: To investigate the relationship between plasma brain natriuretic peptide (BNP) levels and the severity of heart failure, left ventricular function and other factors in patients with heart failure. Methods: The 161 patients were divided into normal control group (n = 42) and HF group (n = 119). Plasma BNP level was measured by radioimmunoassay. The heart color Doppler echocardiography was used to measure and compare the different groups Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDd). Results: BNP levels in patients with heart failure were significantly higher than those in the control group (P <0.01), and BNP levels were significantly increased with the increase of NYHA classification. Heart failure BNP levels, LVEF and LVEDd were significantly different (P <0.05 ~ 0.01). BNP levels were negatively correlated with LVEF (r = -0.685, P <0.001), but positively correlated with LVEDd (r = 0.624, P <0.001). Conclusion: BNP levels in patients with heart failure increase with the severity of heart failure, and can better reflect the functional status of left ventricle.