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目的比较长春瑞滨(NVB)和顺铂(DDP)组成的NP方案时辰化疗与常规化疗治疗非小细胞肺癌(NSCLC)的疗效和不良反应。方法 62例NSCLC患者随机分两组,时辰化疗组32例予NP方案时辰化疗,NVB 25 mg/m2加入生理盐水100 ml,17∶00点静脉滴注10 min,第1,8天;DDP 25mg/m2加入生理盐水500 ml,14∶00～18∶00,用德国产BodyGuard323型正弦曲线输液泵静脉滴注,第2～4天,给药峰值在16∶00点。常规化疗组30例,予NP方案上午时间用药。每例至少完成2周期化疗方评价疗效。结果时辰化疗组有效率为59.4%,常规化疗组有效率为33.3%,两组比较,差异有显著性(P<0.05)。主要不良反应是血液毒性、消化道反应、脱发;时辰化疗组Ⅱ度以上血细胞下降及恶心、呕吐较常规化疗组低(P<0.05)。结论采用NP方案时辰化疗治疗非小细胞肺癌疗效高于常规化疗,毒副反应明显小于常规化疗,在改善患者生活质量方面更具有优势,值得临床进一步研究。
OBJECTIVE: To compare the efficacy and adverse reactions of chemotherapy with conventional regimens in the treatment of non-small cell lung cancer (NSCLC) with NP regimen composed of vinorelbine (NVB) and cisplatin (DDP). Methods Sixty-two patients with NSCLC were randomly divided into two groups. Chemotherapy group (n = 32) received chemotherapy with NP regimen. NVB 25 mg / m 2 was added to 100 ml of normal saline and injected intravenously at 17:00 for 10 min on days 1 and 8. DDP 25 mg / m2 added saline 500 ml, 14:00 ~ 18:00, with a German-made BodyGuard323 sinusoidal infusion pump intravenous infusion, the first 2 to 4 days, peak administration at 16:00. Routine chemotherapy group of 30 cases, to the NP program morning time medication. Each case completed at least 2 cycles of chemotherapy to evaluate efficacy. Results The effective rate was 59.4% in the chemotherapy group and 33.3% in the conventional chemotherapy group. There was significant difference between the two groups (P <0.05). The main adverse reactions were hematologic toxicity, gastrointestinal reaction and alopecia. The blood cell descent and nausea and vomiting of Ⅱ degree and above in chemotherapy group were lower than those in conventional chemotherapy group (P <0.05). CONCLUSION: The time-effect chemotherapy with NP regimen is superior to conventional chemotherapy in chemotherapy of non-small cell lung cancer, and the toxicity is obviously less than that of conventional chemotherapy. It is more advantageous in improving the quality of life of patients and deserves clinical further study.