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[目的]观察茵陈四苓汤结合臭氧治疗对乙肝病毒抑制效果。[方法]使用随机平行对照方法,将71例门诊患者按随机数字表法分为两组。对照组35例,阿德福韦酯(代丁),10mg/次,3次/d,口服。治疗组36例茵陈四苓汤(茯苓、泽泻、白术、猪苓、虎杖、莱菔子各10g,茵陈、丹参各20g,半枝莲、白花蛇舌草各15g,甘草6g,广东一方制药配方颗粒),1剂/d,水溶200mL,早晚口服;臭氧大自血治疗1次/2d。治疗前取患者全血100mL,取100mL臭氧缓慢注入,混匀输回。同时,取300mL臭氧经直肠灌入肠道。两组均连续治疗90d为1疗程。观测HBV-DNA定量、谷丙转氨酶(ALT)、不良反应。治疗1疗程,判定疗效。[结果]HBV-DNA、ALT两组均显著降低(P<0.01),组间无明显差异(P>0.05)。[结论]茵陈四苓汤结合臭氧治疗对乙肝病毒抑制效果显著,值得推广。
[Objective] To observe the inhibitory effect of Yinchen Suling soup combined with ozone on hepatitis B virus. [Method] Using randomized parallel method, 71 outpatients were divided into two groups according to random number table method. Control group 35 cases, adefovir dipivoxil (generation D), 10mg / time, 3 times / d, orally. Treatment group, 36 cases of Yinchen Siling Decoction (Poria, Alisma, Atractylodes, Polyporus umbellatus, Radix Scutellariae each 10g, capillaris, Salvia the 20g, Scutellaria barbata, Hedyotis diffusa each 15g, licorice 6g, Guangdong side of the pharmaceutical formula Particles), 1 / d, water-soluble 200mL, sooner or later orally; ozone treatment of blood from 1 / 2d. Take patients before treatment 100mL whole blood, take 100mL ozone slowly injected, mixed back. At the same time, take 300mL of ozone through the rectum into the intestine. Two groups were treated for 90 days for a course of treatment. Observed HBV-DNA quantitative, alanine aminotransferase (ALT), adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The levels of HBV DNA and ALT in both groups were significantly decreased (P <0.01), but there was no significant difference between the two groups (P> 0.05). [Conclusion] Yinchen Siling Decoction combined with ozone treatment has significant inhibitory effect on hepatitis B virus and is worth popularizing.