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目的:研究丹红治疗颅内动脉瘤术后迟发性脑血管痉挛(DCVS)的疗效。方法:78例颅内动脉瘤术后患者随机分为治疗组和对照组,治疗组40例,对照组38例。治疗组采用丹红+尼莫地平联合治疗,对照组单用尼莫地平治疗,两组均连用14 d。治疗第3、7、14 d后经颅多普勒(TCD)监测两组患者大脑中动脉(MCA)的平均血流速度及观察术后两组病人DCVS的发生率、脑梗死率及死亡率。结果:治疗组DCVS发生率低于对照组(P<0.05),而两组脑梗死率及死亡率无显著差异(P>0.05)。结论:丹红在防治颅内动脉瘤术后DCVS方面有效。
Objective: To study the effect of Danhong on delayed cerebral vasospasm (DCVS) after intracranial aneurysm surgery. Methods: Seventy-eight patients with intracranial aneurysm were randomly divided into treatment group and control group, with 40 cases in the treatment group and 38 cases in the control group. The treatment group with Danhong + nimodipine combination therapy, the control group was treated with nimodipine, both groups were used for 14 days. The mean blood flow velocity of middle cerebral artery (MCA) and the incidence of DCVS, cerebral infarction rate and mortality in both groups were observed by transcranial Doppler (TCD) on the 3rd, 7th and 14th day after treatment. . Results: The incidence of DCVS in the treatment group was lower than that in the control group (P <0.05). There was no significant difference between the two groups in the incidence of cerebral infarction and mortality (P> 0.05). Conclusion: Danhong is effective in preventing DCVS after intracranial aneurysm surgery.