论文部分内容阅读
分别以7-羟基黄酮、水杨醛、肉桂酸和3-取代-4-氨基-1,2,4-三唑-5-硫酮等为起始原料,根据活性基团拼合原则,经多步反应得到3种类型共15个含1,2,4-三唑杂环结构的黄酮类衍生物。用红外、核磁共振氢谱、质谱及元素分析对化合物的结构进行了确证。测定了新化合物清除超氧自由基(O2-·)、羟自由基(·OH)和2,2-二苯基-1-苦味酰基自由基(DPPH·)的活性及总还原能力。结果表明,在0.5 mg·m L-1浓度时,多数化合物具有抗氧化活性,其中化合物7-(3-间甲苯基-4-水杨醛亚氨基-1,2,4-三唑-5-硫)乙氧基黄酮(5e)对O2-·抑制作用与对照维生素C相当,其余化合物活性均弱于维生素C。
7-hydroxy-flavone, salicylaldehyde, cinnamic acid and 3-substituted-4-amino-1,2,4-triazole-5-thione as the starting material, respectively, according to the principle of active group combination, Three steps were performed to obtain three types of flavonoid derivatives containing 1,2,4-triazole heterocycle. The structures of the compounds were confirmed by IR, 1HNMR, MS and elemental analysis. The activity and total reducing ability of the new compounds to scavenge superoxide radicals (O2-), hydroxyl radicals (· OH) and 2,2-diphenyl-1-picryl radical (DPPH ·) were measured. The results showed that at the concentration of 0.5 mg · m L-1, most of the compounds have anti-oxidative activity. Among them, 7- (3-m-tolyl-4-salicylaldehyde-1,2,4- ) Ethoxyflavone (5e) had similar inhibitory effect on O2- · compared with that of control vitamin C, while other compounds were weaker than vitamin C.