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AIM:To evaluate and compare the effect of combinedtransarterial chemoembolization (TACE) and arterialadministration of Bletilla striata (a Chinese traditionalmedicine against liver tumor) versus TACE alone for thetreatment of hepatocellular carcinoma (HCC) in ACI rats.METHODS:Subcapsular implantation of a solid Morrishepatoma 3 924A (2 mm~3) in the liver was carried out in 30male ACI rats.Tumor volume (V1) was measured by magneticresonance imaging (MRI) on day 13 after implantation.Thefollowing different agents of interventional treatment wereinjected after retrograde catheterization via gastroduodenalartery (on day 14),namely,(A) TACE (0.1 mg mitomycin +0.1 ml lipiodol) + Bletilla striata (1.0 mg) (n=10);(B) TACE+ Bletilla striata (1.0 mg) + ligation of hepatic artery (n=10),(C) TACE alone (control group,n= 10).Tumor volume (V2)was assessed by MRI (on day 13 after treatment) and thetumor growth ratio (V2/V1) was calculated.RESULTS:The mean tumor volume before (V1) and after(V2) treatment was 0.0355 cm~3 and 0.2248 cm~3 in group A,0.0374 cm~3 and 0.0573 cm~3 in group B,0.0380 cm~3 and0.3674 cm~3 in group C,respectively.The mean ratio (V2/V1)was 6.2791 in group A,1.5324 in group B and 9.1382 ingroup C.Compared with the control group (group C),groupB showed significant inhibition of tumor growth (P<0.01),while group A did not (P>0.05).None of the animals diedduring implantation or in the postoperative period.CONCLUSION:Combination of TACE and arterial administration of Bietilla Plus Iigation of he Patieartery is more effective than TACE alone in the treatmentof HCC in rats
AIM: To evaluate and compare the effect of combined transit chemoembolization (TACE) and arterialadministration of Bletilla striata (a Chinese traditional medicine against liver tumor) versus TACE alone for the treatment of hepatocellular carcinoma (HCC) in ACI rats. METHODS: Subcapsular implantation of a solid Morrishepatoma 3 924A (2 mm ~ 3) in the liver was carried out in 30 male ACI rats. Volume volume (V1) was measured by magnetic resonance imaging (MRI) on day 13 after implantation. Following the different agents of interventional treatment were injected after retrograde catheterization via gas introductionodelaction TACE (0.1 mg mitomycin + 0.1 ml lipiodol) + Bletilla striata (1.0 mg) (n = 10); (B) TACE + Bletilla striata Tumor volume (V2) was assessed by MRI (on day 13 after treatment) and the tumor growth ratio (V2 / V1) was calculated .RESULTS: The mean tumor volume before (V1) and after (V2) treatm ent was 0.0355 cm ~ 3 and 0.2248 cm ~ 3 in group A, 0.0374 cm ~ 3 and 0.0573 cm ~ 3 in group B, 0.0380 cm ~ 3 and 0.3674 cm ~ 3 in group C, respectively.The mean ratio (V2 / V1) was 6.2791 in group A, 1.5324 in group B and 9.1382 ingroup C.Compared with the control group (group C), group B showed significant inhibition of tumor growth (P <0.01), while group A did not . Neon of the animals died in implantation or in the postoperative period. CONCLUSION: Combination of TACE and arterial administration of Bietilla Plus I of treatment of he Patieartery is more effective than TACE alone in the treatment of HCC in rats