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肾脏乙醇脱氢酶活性较低,因此对乙醇的解毒能力较差,过量的酒精摄入可引起急性肾功能衰竭,酒精对肾结构和功能的影响已有研究,但其生化改变仍然不甚清楚,在本文作者过去的研究中指出大鼠摄入乙醇,氨代谢发生改变,本文报道了肾脏酶的活性和氨的产生、代谢的影响。实验用Wistar雄性大鼠,腹腔注射乙醇,每日5次,每次5 g/kg体重,连续注射5日,处死动物,取出肾脏,在介质中匀化,5000 g
Kidney alcohol dehydrogenase activity is low, so less able to detoxify ethanol, excessive alcohol intake can cause acute renal failure, alcohol on the structure and function of renal have been studied, but the biochemical changes are still not clear , The authors in the past study pointed out that rats ingestion of ethanol, ammonia metabolism changes, this article reported the activity of renal enzymes and ammonia production, metabolism. Experimental Wistar male rats were injected intraperitoneally with ethanol five times a day for 5 g / kg body weight for 5 consecutive days. The animals were sacrificed and the kidneys were removed and homogenized in medium at 5000 g