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moyamoya病的病因的仍不清,常呈家族性提示其发病可能有遗传因素。作者研究日本moyamoya病患者Ⅰ、Ⅱ类人类白细胞抗原(HLA)。 研究经脑血管造影证实的32例moyamoya病患者女26例,男6例,平均20.7岁HLA——A、B、C、DR型,其中29例检测了DQ型。178名无脑血管病史对照者检测HLA——A、B、C、DR型,其中54例检测了DQ型。患者和对照者问HLA频率用F和X~2检验,各型检测例数HLA—A10例、B18例,C6例、DR14例、DQ4例相乘进一步校正其概率。结果:moyamoya病平均发病年龄10.5岁。27例(84％)20岁前发病(儿童moyamoya病),5例20岁后发病(成
The etiology of moyamoya disease is still unclear, often familial suggests that its incidence may have genetic factors. The study of Japanese patients with moyamoya disease Ⅰ, Ⅱ class of human leukocyte antigen (HLA). Twenty - six patients with moyamoya disease confirmed by cerebral angiography were studied in 26 patients, including 6 males and 20.7 years old with HLA - A, B, C and DR genotypes. DQ was detected in 29 of 29 moyamoya patients. 178 control subjects without cerebrovascular disease detected HLA - A, B, C, and DR types, and 54 of them tested DQ type. Patients and controls asked HLA frequency using F and X ~ 2 test, each type of test cases of HLA-A10 cases, B18 cases, C6 cases, DR14 cases, DQ4 cases multiplied to further correct its probability. Results: The average onset age of moyamoya disease was 10.5 years. 27 (84%) had onset before 20 years (moyamoya disease in children) and 5 had onset after 20 years