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目的：研究不同强度噪声暴露后成年大鼠蜗核酸性纤维母细胞生长因子（ａＦＧＦ）样免疫反应。方法：噪声暴露后用定量免疫细胞化学方法。结果：１３０ｄｄＢ噪声暴露后１ｄ（１３０ｄＢＳＰＬ，８ｋＨｚ白噪声），ａＦＧＦ样免疫反应明显下降，其下降水平持续１～２月。１２０ｄＢ噪声暴露后１ｄ（１２０ｄＢＳＰＬ，８ｋＨｚ白噪声），ａＦＧＦ样免疫反应也下降，但在１～２月内恢复，蜗核神经元ａＦＧＦ样免疫反应光密度变化似乎与听觉脑干反应相关。结论：本研究表明噪声暴露可造成蜗核神经元ａＦＧＦ样免疫反应低下
OBJECTIVE: To study cochlear nucleic acid fibroblast growth factor (aFGF) -like immunoreactivity in adult rats after exposure to different intensities of noise. Methods: Quantitative immunocytochemical method after noise exposure. Results: The level of aFGF-like immunoreactivity was significantly decreased 1 d after 130ddB noise exposure (130dB SPL, 8kHz white noise), and its decline continued for 1 ~ 2 months. One day after exposure to 120 dB noise (120 dB SPL, 8 kHz white noise), the aFGF-like immunoreactivity was also decreased. However, the recovery of aFGF-like immunoreactivity in cochlear neurons after 1 to 2 months appeared to be associated with auditory brainstem response. CONCLUSIONS: This study shows that noise exposure can cause low aFGF-like immunoreactivity in cochlear neurons