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目的了解医院内分离的耐甲氧西林葡萄球菌(MRS)增高是否与第三代头孢菌素的使用增加相关,为抗生素的规范使用提供依据。方法回顾1997年~2001年间,每年10月份MRS的分离率及全院抗生素及第三代头孢菌素的使用情况,用相关系数表示两者的相关性。结果1997年~2001年抗生素的总使用率下降,由1997年的79.6%降到2001年的69.0%,而第三代头孢菌素的使用率显著增加,由1997年的8.61%到2001年的18.66%;MRS的增加与抗生素的总使用率无关而与第三代头孢菌素的使用呈正相关(r=0.9511,P<0.01)。结论虽然抗生素的总使用率下降,但第三代头孢菌素的使用增加,MRS的增加与第三代头孢菌素的使用呈正相关。
Objective To understand whether the increase of methicillin-resistant Staphylococcus aureus (MRS) isolated in the hospital is related to the increase of the third generation cephalosporins and provide basis for the standard use of antibiotics. Methods From 1997 to 2001, the isolation rate of MRS and the usage of antibiotics and the third generation cephalosporins in the hospital from October to October each year were analyzed. Correlation coefficients were used to show the correlation between them. Results The overall antibiotic use rate dropped from 79.6% in 1997 to 69.0% in 1997 from 1997 to 2001, while the third generation cephalosporin utilization rate increased significantly from 8.61% in 1997 to 18.66%. The increase of MRS was positively correlated with the use of the third generation cephalosporins (r = 0.9511, P <0.01) regardless of the total antibiotic usage rate. Conclusions Although the overall antibiotic use rate decreased, the use of third-generation cephalosporins increased. The increase of MRS was positively correlated with the third-generation cephalosporin use.