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目的:探讨血红素加氧酶-1(heme oxygenase-1,HO-1)、血管内皮生长因子(vascular endothelial growth factor,VEGF)在心脏性猝死病人心室肌细胞中的表达及其意义。方法:运用免疫组织化学方法和Simple PCI图像分析系统观察33例心脏性猝死组和18例非心脏性猝死对照组尸检心肌组织中HO-1、VEGF蛋白的表达情况。结果:心脏性猝死组心肌组织HO-1(155.090±8.957)和VEGF蛋白表达(121.020±10.927)均显著高于非心脏性猝死对照组(116.200±6.355、84.207±4.402,均p<0.05)。结论:HO-1和VEGF蛋白在心脏性猝死者心肌组织表达增强,可能与心脏性猝死有一定关系。
Objective: To investigate the expression and significance of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF) in ventricular myocytes of patients with sudden cardiac death. Methods: The expression of HO-1 and VEGF in 33 cases of sudden cardiac death group and 18 cases of non-cardiac sudden death control group were observed by immunohistochemistry and Simple PCI image analysis system. Results: The levels of HO-1 (155.090 ± 8.957) and VEGF (121.020 ± 10.927) in patients with sudden cardiac death were significantly higher than those in non-cardiac sudden death patients (116.200 ± 6.355, 84.207 ± 4.402, all p <0.05). Conclusions: The expression of HO-1 and VEGF protein in myocardial tissue of sudden cardiac death increased, which may be related to sudden cardiac death.