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目的:对延期妊娠孕妇静脉滴注两种浓度缩宫素,并测试宫颈阴道分泌物中胎儿纤连蛋白(Fetal F ibronectin,FFN)的变化,比较两种浓度缩宫素促宫颈成熟的引产效果。方法:选择120例孕41~41+6周延期妊娠初产妇,随机分成两组,分别应用0.2%和0.5%缩宫素引产,观察两组宫颈B ishop评分、宫颈阴道分泌物FFN的变化并比较其引产效果。结果:两种浓度缩宫素促宫颈成熟率、FFN测试阳性率、分娩率及FFN阳性分娩率无明显统计学差异(P>0.05),对宫颈B ishop评分≥7分者,其促宫颈成熟率、分娩率及FFN测试阳性分娩率均高于同组≤6分者,差异有统计学意义(P<0.05),其分娩率与FFN测试阳性结果呈一致性。结论:延期妊娠低浓度缩宫素引产效果可靠,宫颈阴道分泌物FFN测试阳性是宫颈成熟、分娩即将发动的标志。宫颈B ishop评分≤6分宜选用0.2%缩宫素促宫颈成熟,对于宫颈B ishop评分≥7分、FFN测试阳性孕妇,宜选用0.5%缩宫素促宫颈成熟引产。
OBJECTIVE: To evaluate the changes of Fetal Fibronectin (FFN) in pregnant women with postprandial pregnancy by intravenous infusion of two concentrations of oxytocin and compare the effects of oxytocin at two concentrations on the induction of cervical ripening . Methods: 120 primiparae of pregnancy with 41 ~ 41 + 6 weeks delayed gestation were randomly divided into two groups. Induction of oxytocin at 0.2% and 0.5% respectively was used to observe the change of cervical B-ishop score and cervix vaginal secretion FFN Comparison of its induction effect. Results: There was no significant difference in the rates of cervical ripening, FFN test positive rate, delivery rate and FFN positive childbirth rate between two concentrations of oxytocin (P> 0.05) Rate, delivery rate and FFN test positive childbirth rate were higher than the same group of ≤ 6 points, the difference was statistically significant (P <0.05), the delivery rate and FFN test positive results were consistent. CONCLUSION: Ovarian oxytocin with prolonged pregnancy has a reliable induction of labor and positive FFN test of cervicovaginal secretions is a sign that the cervix is mature and delivery is about to start. Cervical B ishop score ≤ 6 points should choose 0.2% oxytocin to promote cervical maturity, cervical B ishop score ≥ 7 points, FFN test positive pregnant women, should choose 0.5% oxytocin to promote cervical ripening.