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目的:探讨生殖道感染对早中期妊娠结局的影响。方法:对进行产前保健并决定分娩的孕妇在初产检时行ToRCH(包括弓形虫、巨细胞病毒、风疹病毒、单纯疱疹病毒)、白带常规(包括念珠菌、滴虫、细菌性阴道病)、衣原体、支原体及阴道分泌物细菌培养及药物敏感试验检查,分为感染组和非感染组,并将感染组分为感染治疗组与感染非治疗组,追踪3组患者不良妊娠结局的发生情况。结果:有病原微生物感染所造成的不良妊娠结局明显高于无感染者(P<0.05),感染非治疗组的不良妊娠结局率明显高于感染治疗组(P<0.05);单一感染感染非治疗组的不良妊娠结局率明显高于感染治疗组(P<0.05),多种感染感染非治疗组的不良妊娠结局率明显高于感染治疗组(P<0.05)。结论:孕妇孕早中期病原微生物感染会增加不良妊娠结局的发生率,对妊娠妇女需进行常规生殖道感染方面检查、对妊娠妇女合并生殖道感染需积极抗感染治疗有重要的临床指导意义。
Objective: To investigate the effect of genital tract infection on early pregnancy outcome. Methods: ToRCH (including Toxoplasma gondii, cytomegalovirus, rubella virus and herpes simplex virus), vaginal discharge routine (including Candida, trichomonas, bacterial vaginosis) , Chlamydia, mycoplasma and vaginal secretions bacterial culture and drug sensitivity test, divided into infection group and non-infected group, and the infection was divided into infection treatment group and infection non-treatment group, tracking the incidence of adverse pregnancy outcomes in 3 groups . Results: The adverse pregnancy outcomes caused by pathogenic microorganisms were significantly higher than those without infection (P <0.05). The adverse pregnancy outcomes in non-infected patients were significantly higher than those in infected patients (P <0.05) Adverse pregnancy outcomes were significantly higher in the untreated group than in the infected patients (P <0.05). The prevalence of adverse pregnancy in the non-treated group was significantly higher than that in the infected patients (P <0.05). Conclusion: The infection of pathogenic microorganisms in pregnant women during the first trimester may increase the incidence of adverse pregnancy outcomes. It is necessary to check the routine reproductive tract infections in pregnant women. It is of great clinical significance for active anti-infective therapy in pregnant women with genital tract infections.