双重用药治疗停服阿片药物后出现的神经行为反应的疗效

• 作 者: CoyleM. G. Ferguson A. LaGasse L. 宁亮
• 机 构: Department of Pediatrics Brown Medical School Women and Infants Hospital 101 Dudley Street Providen
• 出 处: 世界核心医学期刊文摘(儿科学分册)
• 发表日期: 2005年09期
• 关键词: 阿片药物 神经行为 用药 出生后 临床对照试验 神经系统反应 阿片酊 苯巴比妥 联合疗法 反射中枢

A partially randomised, controlled trial was performed to test the hypothesis that opiate exposed infants treated with diluted tincture of opium (DTO) and phenobarbital would have better neurobehavioral scores than infants treated with DTO alone. Compared with those treated with DTO alone (n = 15), infants treated with DTO and phenobarbital (n = 17)were more interactive, had smoother movements, were easier to handle, and less stressed. Dual treatment results in improved neurobehavioral organisation during the first three weeks of life, which may indicate a more rapid recovery from opiate withdrawal.

Compared with those treated with DTO alone (n = 15 ), infants treated with DTO and phenobarbital (n = 17) were more interactive, had smoother movements, were easier to handle, and less stressed. Dual treatment results in the first three weeks of life, which may indicate a more rapid recovery from opiate withdrawal.