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报告了该院1981年10月～1984年8月应用本药治疗心律失常88例,其中70例为住院治疗;过去曾用过一种以上抗心律失常药治疗无效者47例。总有效率为84.09％(显效者39.8％);以室上性心动过速、阵发性房颤、房早、室早疗效较高。 本文着重讨论了本药的不良反应: 心血管系统反应较多,往往是危及生命的主要原因,我省因本药致死者已在10例以上。本组发生率为52.27％,以Q—Tc延长超过治疗前23％者为多(占21.59％),本组有二例分别服药20天(风心、持续房颤)及8天(肺心、频发室早),因Q—Tc延长>23％而停药,分别在停药后二天及一天发生阿一斯综合征,一例抢救无效死亡。本药吸收、排泄缓慢,有积蓄作用,故治疗中必须严密观
Report of the hospital from October 1981 to August 1984 the application of the drug to treat 88 cases of arrhythmia, of which 70 cases were hospitalized; in the past have used more than one type of antiarrhythmic drug treatment in 47 cases. The total effective rate was 84.09% (39.8% were markedly effective); supraventricular tachycardia, paroxysmal atrial fibrillation, Fang Zaowa, early room curative effect is higher. This article focuses on the adverse reactions of this drug: cardiovascular system reaction is more often the main cause of life-threatening, our province has been caused by the drug more than 10 cases. The incidence of this group was 52.27%, Q-Tc prolonged more than 23% before treatment were more (21.59%), two patients in this group were taken for 20 days (wind heart, persistent atrial fibrillation) and 8 days , Frequent room early), due to Q-Tc prolonged> 23% and withdrawal, respectively, two days after stopping and the occurrence of Alsar’s syndrome one day, died of an invalid rescue. The drug absorption, excretion slow, there is savings, so the treatment must be closely watched