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目的评价胃、大肠癌患者术前肠外营养和化疗的作用.方法胃、大肠癌患者92例,随机分成4组,术前分别给7d肠外营养(组Ⅰ)、化疗(组Ⅱ)、肠外营养加化疗(组Ⅲ)及口服普食(组Ⅳ).治疗前后分别测体重、氮平衡(9N/24h),血淋巴细胞计数(L计数,×109/L),白蛋白(g/L)、前白蛋白(mg/L)、转铁蛋白(g/L)、补体C3(g/L),IgA,IgG,IgM(g/L)及癌细胞DNA含量(pg/L)、DNA指数和细胞周期时相.结果与治疗前相比,治疗后组Ⅰ(n=23)氮平衡(-10±05vs38±02,P<001)、L计数(185±023vs210±024,P<001)、前白蛋白(252±75vs290±33,P<001)、转铁蛋白(26±02vs33±01,P<001)、IgA(211±021vs252±020,P<001)、IgM(185±019vs238±019,P<001)及癌细胞DNA含量(747±045vs996±017,P<005,860±178vs1710±264,P<005)和指数(164±015vs229±0?
1. Objective To evaluate the role of preoperative parenteral nutrition and chemotherapy in gastric and colorectal cancer patients. Methods Ninety-two patients with gastric and colorectal cancer were randomly divided into 4 groups. Preoperative parenteral nutrition (Group I), chemotherapy (Group II), parenteral nutrition plus chemotherapy (Group III) and oral general food (Group IV) were given before surgery. . Weight, nitrogen balance (9N/24h), blood lymphocyte count (L count, ×109/L), albumin (g/L), prealbumin (mg/L), transferrin (g) were measured before and after treatment. /L), complement C3 (g/L), IgA, IgG, IgM (g/L), and cancer cell DNA content (pg/L), DNA index, and cell cycle phase. Results Compared with before treatment, group I (n=23) nitrogen balance after treatment (-10±05vs38±02, P<001), L count (185±0) 23vs210±024, P<001), prealbumin (252±75vs290±33, P<001), transferrin (26±02vs33±) 01, P<001), IgA (211±021vs252±020, P<001), IgM (185±019vs238±019, P<001) and DNA content of cancer cells (747±045vs996±017, P<005,860±178vs1710±264, P<0 05) and the index (164±015vs229±0?