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目的观察碳酸锂联合康复训练治疗缺血性脑卒中的疗效。方法将67例缺血性脑卒中的患者随机分为碳酸锂治疗组和安慰剂组,两组患者均同时接受康复训练。采用改良Barthel指数(modified Barthel index,MBI)和简化Fugl-Meyer运动功能量表(Fugl-Meyer assessment,FMA)评定两组患者的日常生活活动能力(activties of daily living,ADL)和运动功能,用改良Ashworth痉挛分级法(Modified Ashworth Scale for Spasticity,MAS)评定其肌痉挛的程度。结果治疗3个月后两组患者MBI及FMA两项评分均有明显改善(P<0.05),碳酸锂治疗组的疗效优于对照组(P<0.05),改良Ashworth痉挛分级等级下降。结论缺血性脑卒中患者给予碳酸锂和康复训练后可促进其运动功能的恢复,提高日常生活活动能力,这种效应可能是通过锂的神经营养和神经保护而起作用。
Objective To observe the effect of lithium carbonate combined with rehabilitation training on ischemic stroke. Methods Sixty-seven patients with ischemic stroke were randomly divided into lithium carbonate group and placebo group. Both groups received rehabilitation training at the same time. The modified Barthel index (MBI) and the simplified Fugl-Meyer assessment of motor function (FMA) were used to assess the activities of daily living (ADL) and motor function in both groups Modified Ashworth Scale for Spasticity (MAS) was used to assess the extent of muscle spasms. Results Both MBI and FMA scores improved significantly in both groups (P <0.05) after treatment for 3 months. The effect of lithium carbonate in treatment group was better than that in control group (P <0.05), and grade of modified Ashworth spasm was decreased. Conclusion Lithium carbonate and rehabilitation training can promote the recovery of motor function and improve the activities of daily living in ischemic stroke patients. The effect may be through the neurotrophic and neuroprotective effects of lithium.