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本研究观察了大鼠急性心肌梗塞(AMI)经乳清酸治疗(AMIOA)和生理盐水治疗(AMINS)后梗塞面积、非梗塞区心肌肥大及能量的改变。结果表明:在AMI后1,3,7,14d,AMIOA与AMINS组梗塞面积无明显区别(P>0.05);在AMI后14d,AMIOA组大鼠体重明显高于AMINS组(P<0.05);梗塞后7,14d,AMIOA、AMINS两组全心重量、右室重量体重比、心脏重量/体重比相近,但高于假手术组(SONS)(P<0.05);AMIOA组非梗塞区心肌ATP、CP含量高于AMINS组(P<0.01～0.05),与SONS组相近(P>0.05)。提示:乳清酸治疗AMI,不扩大心肌梗塞面积,且有利于体重的恢复,改善非梗塞区能量代谢。
In this study, we investigated the changes of infarct size, myocardial hypertrophy and energy in non-infarcted areas after acute myocardial infarction (AMI) in rats treated with orotic acid (AMIOA) and normal saline (AMINS). The results showed that there was no significant difference in the infarct size between AMIO and AMINS at 1, 3, 7 and 14 days after AMI (P>0.05). At 14 days after AMI, the weight of rats in AMIOA group was significantly higher than that of AMINS group (P<0.05). At 7 and 14 days after infarct, the heart weight, right ventricular mass ratio, and heart weight/body weight ratio were similar between AMIO and AMINS, but higher than those in the sham operation group (SONS) (P < 0.05). Myocardial ATP in the non-infarcted region of the AMIOA group. The content of CP was higher than that of AMINS group (P<0.01-0.05) and similar to that of SONOS group (P>0.05). Tip: Orotic acid treatment of AMI does not increase myocardial infarct size, and is beneficial to the recovery of body weight and improves energy metabolism in non-infarcted areas.