论文部分内容阅读
目的 研究大鼠侧脑室内注射 (icv)神经降压素 (NT)所致降压反应的中枢机制。方法 用乌拉坦麻醉雄性 SD大鼠 (3 0只 ) ,将 NT icv,观察其血压 (BP)和心率 (HR)的变化。然后分别 icv M受体阻断剂硫酸阿托品和切断两侧颈部迷走神经 ,再 icv NT,观察 BP和 HR的变化。结果 icv NT (10μg/鼠 )可引起 BP升高或降低 ,HR减慢。预先 icv阿托品 2 .5μg,可阻断 NT的中枢降压反应 ;切断两侧颈部迷走神经可减弱 NT的中枢心血管抑制效应。结论 脑中 NT含量升高可使血压升高或降低 ,NT引起的中枢心血管抑制效应主要是由于心迷走神经系统活动加强所致
Objective To investigate the central mechanism of antihypertensive response induced by intracerebroventricular injection of icv (NT) in rats. Methods Thirty male Sprague-Dawley rats were anesthetized with urethane, and NT icv was used to observe the changes of blood pressure (BP) and heart rate (HR). Then respectively icv M receptor blocker atropine sulfate and cut off both sides of the neck vagus nerve, and then icv NT, observed BP and HR changes. Results icv NT (10 μg / mouse) caused either elevated or decreased BP and slowed HR. Pre-icv atropine 2.5μg, can block the central NT antihypertensive response; cut off both sides of the neck vagus nerve can reduce NT central cardiovascular inhibitory effect. Conclusions The increase of NT in the brain may increase or decrease the blood pressure. The central cardiovascular inhibitory effect caused by NT is mainly attributed to the increased activity of the heart and vagus nerve system