【摘 要】
：
A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adenosylL-homocysteine hydrolase(SAHase) inhi
【机 构】
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College of Pharmacy, Guilin Medical University,Department of Medicinal Chemistry and Pharmacognosy,
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adenosylL-homocysteine hydrolase(SAHase) inhibitory activity. Among these compounds, 8b,8m, 8r and 8w showed better or similar inhibitory effects compared to the positive control aristeromycin. These results provide a novel lead for the discovery of more potent non-adenosine analogs as SAHase inhibitors.
A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adenosyl L-homocysteine hydrolase (SAHase) inhibitory activity. These these compounds, 8b, 8m, 8r and 8w showed better or similar inhibitory effects compared to the positive control aristeromycin. These results provide a novel lead for the discovery of more potent non-adenosine analogs as SAHase inhibitors.
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