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Objective The purpose of this study was to compare orally administere d misopro stol with intravenous oxytocin infusion for labor induction in women with favora ble cervical examinations (defined as a Bishop score of 6 or more). Study design One hundred ninety-eight women with indications for labor induction and favora ble cervical examinations were assigned randomly to receive oral misoprostol or oxytocin induction. Misoprostol, 100 mg, was administered every 4 hours up to 6 doses, or intravenous oxytocin was administered by standardized protocol. Results One hundred ten (55.6%) women received misoprostol; 88 (44.4 %) received intravenous oxytocin. There was no statistically significant differ ence in the average interval from start of induction to vaginal delivery, being longer in the misoprostol group (789.4 ±510.2 minutes) than in the oxytocin gro up (654.0 ±338.2 minutes, P=.19, log-transformed data). Two women had tachysys tole develop in each treatment group. More women in the misoprostol group experi enced hyperstimulation (7/110, 6.4%) than in the oxytocin group (0/88, P=.02, F isher exact test). Nine (8.1%) misoprostol-treated women and 8 (9.1%) oxytoci n-treated women underwent cesarean deliveries (P=.82). There was a presumed ute rine rupture in a misoprostol-treated multipara women. There were no statistica lly significant differences in neonatal outcomes between the groups. Conclusion Oral misoprostol offers no benefit over intravenous oxytocin for labor induction in women with favorable cervical examinations. It is associated with a higher l ikelihood of uterine hyperstimulation and may increase the risk of uterine ruptu re.
Objective The purpose of this study was to compare orally administere d misopro stol with intravenous oxytocin infusion for labor induction in women with favora ble cervical examinations (defined as a Bishop score of 6 or more). Study design One hundred ninety-eight women with indications for labor induction and favora bleaches examines were assigned random to receive oral misoprostol or oxytocin induction. Misoprostol, 100 mg, was administered every 4 hours up to 6 doses, or intravenous oxytocin was administered by standardized protocol. Results One hundred ten (55.6% There was no significant change in the interval between start of induction to vaginal delivery, being longer in the misoprostol group (789.4 ± 510.2 minutes) than in the oxytocin gro up (654.0 ± 338.2 minutes, P = .19, log-transformed data). Two women had tachysys tole develop in each treatment group. Nine (8.1%) misoprostol-treated women and 8 (9.1%) oxytoci (7%, 6.4%) than in the oxytocin group There was no statistica lly significant differences in neonatal outcomes between the groups. Conclusion Oral misoprostol offers no benefit over (P = .82). There was a presumed ute rine rupture in a misoprostol-treated multipara women. intravenous oxytocin for labor induction in women with satisfactory cervical examinations. It is associated with a higher likelihood of uterine hyperstimulation and may increase the risk of uterine ruptu re.