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红霉素注射液在 pH 6～8时较稳定,不宜加入葡萄糖注射液中静滴。红霉素在 pH4.2时28分钟可分解10％,pH4.8时81分钟可分解10％,pH5.3时16小时才分解10％。我院配制的5％葡萄糖注射液的 pH 在3.7～4.0,注射用生理盐水 pH 在5.8～6.0。所以红霉素加入生理盐水中静滴较妥。当遇有忌盐者,则可在葡萄糖注射液中加入5％碳酸氢钠注射液使 pH 达5.5以上进行静滴。笔者用100毫升5％葡萄糖注射液加入5％碳酸氢钠注射液0.1毫升,pH 值可由3.8上升为6.6。
Erythromycin injection at pH 6 ~ 8 is more stable, should not be added to intravenous infusion of glucose. Erythromycin can decompose 10% at 28 minutes at pH 4.2, 10% at 81 minutes at pH 4.8, and 10% at 16 hours at pH 5.3. The 5% glucose injection prepared in our hospital has a pH between 3.7 and 4.0, and physiological saline for injection has a pH between 5.8 and 6.0. So erythromycin intravenous infusion of saline better. In case of avoid salt who can add 5% sodium bicarbonate injection in glucose injection to pH 5.5 or more for intravenous infusion. I use 100 ml 5% glucose injection 5% sodium bicarbonate injection 0.1 ml, the pH value can be increased from 3.8 to 6.6.