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[目的]探讨放疗联合唑来膦酸治疗脊柱转移癌所致疼痛及截瘫的疗效。[方法]56例恶性肿瘤脊柱转移伴疼痛及肢体活动不灵患者,采用6MVX常规分割放疗,同期给唑来膦酸4mg+生理盐水100ml静滴,3~4周重复,至少连续2次。观察疼痛症状及生活质量改善情况的变化。[结果]56例87个放疗部位止痛总有效率94.3%,生活质量明显改善,总有效率94.7%,20例活动受限的患者中,下肢活动能力评价总有效率90.0%。[结论]放疗联合唑来膦酸在防治脊柱转移癌所致疼痛及截瘫方面有显著疗效,值得临床推广。
[Objective] To investigate the curative effect of radiotherapy and zoledronic acid on pain and paraplegia caused by spinal metastasis cancer. [Method] Fifty-six patients with spine metastasis of malignant tumor accompanied by pain and physical immobility were treated with 6MVX conventional radiotherapy. In the same period, 4 mg of zoledronic acid and 100 ml of normal saline were intravenously dripped and repeated 3 to 4 weeks for at least two consecutive times. Observe the changes of pain symptoms and quality of life. [Results] The total effective rate of pain relief was 94.3% in 87 radiotherapy sites, the quality of life improved significantly, the total effective rate was 94.7%. Among 20 patients with limited mobility, the total effective rate of lower limb activity evaluation was 90.0%. [Conclusion] The combination of radiotherapy and zoledronic acid has significant curative effect in preventing pain and paraplegia caused by spinal metastases, and is worthy of clinical promotion.