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目的：考察依布硒啉（ｅｂｓｅｌｅｎ）对肝损伤的保护作用。方法：以０２％四氯化碳（５ｍｌ·ｋｇ－１）和内毒素（１μｇ·ｋｇ－１）＋Ｄ氨基半乳糖（８００ｍｇ·ｋｇ－１）分别ｉｐＩＣＲ小鼠形成肝损伤，观察病理改变及血清谷丙转氨酶（ＡＬＴ）、总胆红素（ＴＢＩＬ）和总胆汁酸（ＴＢＡ）活性。培养大鼠肝细胞以ＣＣｌ４和ＬＰＳ＋ＤＧａｌＮ诱发损伤。测定了乳酸脱氢酶活性和细胞ＴＢＡＲＳ含量。结果：依伯硒啉可改善ＣＣｌ４和ＬＰＳ＋ＤＧａｌＮ诱发的小鼠肝损伤变化，减小相关损伤指标的改变；并可拮抗培养肝细胞的ＬＤＨ释放和ＴＢＡＲＳ含量上升。结论：依布硒啉能保护肝损伤，可能与抗自由基的脂质过氧化有关。
Objective: To investigate the protective effect of ebselen on liver injury. Methods: Liver injury was induced by ipICR in 02% carbon tetrachloride (5ml · kg-1), endotoxin (1μg · kg-1) and D-galactosamine (800mg · kg- Change and serum ALT, TBIL and TBA. CCl4 and LPS + DGalN were induced to induce injury in rat hepatocytes. Lactate dehydrogenase activity and cell TBARS content were determined. Results: Ebselen improved the hepatic injury induced by CCl4 and LPS + DGalN, reduced the changes of related injury indexes, and inhibited the release of LDH and the increase of TBARS in cultured hepatocytes. Conclusion: Ebselen can protect liver injury and may be related to the anti-free radical lipid peroxidation.