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A high-efficiency liquid dishwashing detergent was prepared by using oregano essential oil as an antibacterial agent. The surface cleaning and antibacterial property of the detergent resolved its unifunctionality problem. The antibacterial activities of the detergent were demonstrated through a disk diffusion assay and wipe experiments with Escherichia coli and Staphy-lococcus aureus. Results showed that the prepared detergent was highly effective against E. coli and S. aureus. The results of chemical accelerated tests indicated that the detergent would be effective for at least 1 year. The antibacterial property and detergency performance of the high-efficiency antibacterial liquid dishwashing detergent were compared with those of a commercial antibacterial detergent containing 0.02% o-phenylphenol. The detergency performance of the high-efficiency detergent reached 97.8% and was superior to that of the commercial antibacterial detergent.