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目的探讨高砷饮水对孕期妇女T淋巴细胞、免疫球蛋白和白细胞介素-2水平的影响。方法高砷饮水地区168名孕期妇女,根据水砷含量分为对照组(48例)、低暴露组(60例)和高暴露组(60例)。对所有孕期妇女尿砷含量进行检测,并检测T淋巴细胞、免疫球蛋白和白细胞介素-2水平情况。结果高暴露组尿砷、水砷含量、CD4+亚群百分含量均值、CD4+/CD8+均值、IgG、IgM与对照组、低暴露对比,差异有统计学意义(P<0.05)。结论孕期妇女长期饮用高砷水会显著降低体液免疫功能,但对白细胞介素-2水平无显著影响。
Objective To investigate the effects of high arsenic drinking water on the levels of T lymphocyte, immunoglobulin and interleukin-2 in pregnant women. Methods 168 pregnant women with high arsenic drinking water were divided into control group (48 cases), low exposure group (60 cases) and high exposure group (60 cases) according to the water arsenic content. Arsenic levels in all pregnant women were tested and T lymphocytes, immunoglobulins and interleukin-2 levels were measured. Results The arsenic and water contents of arsenic and water in high exposure group were significantly lower than those in control group and low exposure group (P <0.05). Conclusion Long-term high-arsenic water consumption during pregnancy significantly reduces humoral immune function, but has no significant effect on interleukin-2 levels.