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目的:探讨染色体异常和不良孕产史的关系。方法:对200对有不良孕产史的夫妇(研究组)及100对已正常生育子女的夫妇(对照组)进行外周血染色体分析。结果:在有不良孕产史的夫妇中异常发生率为7.0%,显著高于对照组(P<0.01),在28例异常核型中男性18例占64.3%,女性10例占35.7%。异常核型中性染色体数目异常2例占7.1%,常染色体结构异常15例占53.5%,染色体多态性11例占39.3%。结论:染色体异常是导致不良孕产史的重要遗传学原因,对其进行染色体检查有助于病因的分析与诊断,并为生育指导提供重要的依据。
Objective: To investigate the relationship between chromosomal abnormalities and poor pregnancy history. Methods: Peripheral blood chromosomal analysis was performed on 200 pairs of couples with a history of poor pregnancy (study group) and 100 pairs of couples who had a normal childbirth (control group). Results: The abnormal incidence rate was 7.0% in couples with adverse pregnancy history, which was significantly higher than that in control group (P <0.01). Among 28 abnormal karyotypes, 18 males accounted for 64.3% and females 10% (35.7%). Abnormal karyotype number of anomalous 2 cases accounted for 7.1%, 15 cases of an autosomal abnormality accounted for 53.5%, 11 cases of chromosome polymorphism accounted for 39.3%. Conclusion: Chromosomal abnormalities is an important genetic cause of poor maternal history. Chromosome examination is helpful for the analysis and diagnosis of etiology and provides important evidence for guidance of maternity.