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目的探讨早期补救性ICSI在原发不孕患者中的临床应用价值及可行性。方法以行常规IVF-ET治疗原发不孕患者203周期为实验组,进行短时授精结合第二极体观察判断受精情况,对受精失败或受精率低下患者行早期补救性ICSI治疗。并与同期93个直接ICSI周期进行比较。结果 203个周期中行早期补救性ICSI周期17个,占周期总数8.4%;与直接ICSI周期比较,早期补救性ICSI的受精率、多PN(≥3PN)、卵裂率、优质胚胎率、妊娠率、种植率等方面差异无统计学意义。结论早期补救性ICSI在无明确ICSI指证的原发不孕患者中可以获得较好的临床效果。
Objective To investigate the clinical value and feasibility of early salvage ICSI in patients with primary infertility. Methods 203 patients with primary infertility treated with routine IVF-ET were selected as the experimental group. The fertilization was performed by short-time insemination combined with the second polar body observation. The patients were treated with early rescue ICSI for fertilization failure or low fertilization rate. And compared with 93 direct ICSI cycles over the same period. Results In the 203 cycles, 17 early ICSI cycles were rehabilitated, accounting for 8.4% of the total cycles. Compared with the direct ICSI cycle, the fertilization rate, multiple PN (≥3PN), cleavage rate, high quality embryo rate, pregnancy rate , Planting rate and other aspects of the difference was not statistically significant. Conclusion Early salvage ICSI can obtain better clinical results in patients with primary infertility without definite ICSI.