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目的:探讨双歧杆菌三联活菌肠溶胶囊联合蓝光照射治疗新生儿黄疸的临床效果。方法:选择中山市陈星海医院2013年1月至2015年1月病理性黄疸患儿60例,随机分组为观察组和对照组,每组30例,对照组采用单纯蓝光照射方法进行治疗,观察组采用双歧杆菌三联活菌肠溶胶囊联合蓝光照射进行治疗。观察和比较两组患儿的治疗有效率、治疗前后的胆红素水平、黄疸消退时间和不良反应发生率。结果:(1)与对照组66.67%对比,观察组治疗有效率93.33%明显更高,差异具有统计学意义(P<0.05)。(2)与对照组对比,观察组治疗3 d后、治疗5 d后胆红素指数明显更低,消退黄疸时间明显更短,差异具有统计学意义(P<0.05);与入院时对比,两组患儿治疗1 d后、3 d后、5 d后胆红素指数明显降低,差异具有统计学意义(P<0.05)。(3)对照组不良反应发生率为6.67%,观察组不良反应发生率为20%,两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌肠溶胶囊联合蓝光照射治疗新生儿黄疸的临床效果,能够促进新生儿黄疸的消退,降低患儿的血清胆红素浓度,不良反应发生较少。
Objective: To investigate the clinical efficacy of live bifidobacterium triple enteric-coated enteric-coated capsules combined with blue light irradiation in the treatment of neonatal jaundice. Methods: Sixty children with pathologic jaundice from January 2013 to January 2015 in Chen Xinghai Hospital of Zhongshan were randomly divided into observation group (n = 30) and control group (n = 30). The control group was treated by simple blue light irradiation Group Bifidobacterium triple live bacteria enteric-coated capsules combined with blue light irradiation for treatment. Observe and compare the treatment efficiency of two groups of children, bilirubin levels before and after treatment, jaundice subsided time and the incidence of adverse reactions. Results: (1) Compared with 66.67% of the control group, the effective rate of the observation group was 93.33%, the difference was statistically significant (P <0.05). (2) Compared with the control group, after 3 days of treatment, the bilirubin index was significantly lower and the time for regression jaundice was significantly shorter in the observation group after 5 days of treatment, with statistical significance (P <0.05). Compared with the control group, The bilirubin index of the two groups of children after 1 day of treatment was significantly lower than that of the control group after 3 days (P <0.05). (3) The incidence of adverse reactions in the control group was 6.67%, and the incidence of adverse reactions in the observation group was 20%. There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: The clinical efficacy of Bifidobacterium triple viable enteric-coated capsules combined with blue light irradiation in the treatment of neonatal jaundice can promote the regression of neonatal jaundice and reduce the serum bilirubin concentration in children with less adverse reactions.