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目的 研究应激性大鼠血压升高时肾脏结构的变化。方法 给SD大鼠间断性足底电刺激 15d ,隔日监测尾动脉血压 (BP) 1次 ,观察其尾动脉BP的变化情况和第 15天后肾脏肾小球入球小动脉和出球小动脉口径的变化。结果 单纯应激组在第 9、11、13、15天测得BP与对照组相比有明显差异 (P <0 .0 5或P <0 .0 1) ;第 15天后肾脏肾小球入球小动脉和出球小动脉口径的变化与对照组相比没有明显区别 (P >0 .0 5 )。L -ARG +应激组隔日测得BP与对照组相比没有明显差异 ,第 15天测得BP低于对照组 (P <0 .0 5 ) ,BP未升高 ,且有下降的趋势 ,第 15天后肾小球入球小动脉和出球小动脉口径的变化与对照组相比没有明显区别 (P >0 .0 5 )。结论 应激刺激可使BP升高 ,应激性大鼠血压升高的早期肾脏入、出球小动脉结构没有明显变化。
Objective To study the changes of renal structure in stress rats with elevated blood pressure. Methods SD rats were subjected to intermittent electrical stimulation of the soleus for 15 days and caudal arterial pressure (BP) was monitored every other day. The changes of BP in caudal artery and the diameter of renal glomerular afferent arterioles and arterioles The change. Results Compared with the control group, there was significant difference between BP and control group on the 9th, 11th, 13th and 15th days in the simple stress group (P <0.05 or P <0.01) There was no significant difference in the diameter of the arteriolar artery and the arteriolar artery (P> 0.05). There was no significant difference between BP and control group in L-ARG + stress group. BP was lower than control group on the 15th day (P <0.05), BP was not increased, and there was a downward trend, There was no significant difference in the caliber of the glomerular access arterioles and the output arterioles after 15 days (P> 0.05). Conclusion The stress stimulation can make BP rise, and the structure of arteriolar inflow and ectocoronary arteriole in the early stage of hypertension in stress rats has no obvious change.