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目的 探讨毛细支气管炎吸入皮质激素与预防儿童哮喘发病的关系。方法 5 2例毛细支气管炎患儿间断吸入丙酸倍氯米松 1.5～ 2年后 ,测其骨密度值。随访 3～ 4年 ,并测其气道反应性。结果 5 2例中有 4例发展为哮喘 ,而对照组5 0例中 16例发展为哮喘 ,两组比较差异有极显著意义 (P <0 .0 1)。超声雾化蒸馏水激发试验 (UNDW )显示吸入治疗组 3例阳性 ,而对照组 13例阳性 ,两组比较差异有极显著意义 (P <0 .0 1)。吸入组治疗前后骨密度值差异无显著意义 (P >0 .0 5 )。结论 毛细支气管炎患儿吸入皮质激素治疗有利于预防哮喘发病
Objective To investigate the relationship between inhaled corticosteroid and the prevention of asthma in children with bronchiolitis. Methods 52 cases of bronchiolitis children intermittent inhalation of beclomethasone propionate after 1.5 to 2 years, measured the bone mineral density value. Followed up for 3 to 4 years and measured airway responsiveness. RESULTS: Four out of 52 cases developed asthma, whereas 16 out of 50 cases in the control group developed asthma. There was significant difference between the two groups (P <0.01). Ultrasound nebulized distilled water challenge test (UNDW) showed that inhalation therapy group, 3 cases were positive, while the control group, 13 cases were positive, the difference between the two groups was extremely significant (P <0. There was no significant difference in BMD before and after inhalation (P> 0.05). Conclusion The inhaled corticosteroid in children with bronchiolitis is good for the prevention of asthma