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目的:弓形虫作为专性细胞内寄生的医学原虫在妇幼保健方面已经引起了广泛的关注,研究中药蒿甲醚在治疗弓形虫感染中的作用,为临床弓形虫感染患者特别是孕妇提供新的治疗策略。方法:建立弓形虫感染的小鼠模型,将感染弓形虫的小鼠分为两组,分别给予蒿甲醚和磺胺嘧啶钠治疗。观察各组小鼠的存活情况,并且采用PCR方法取小鼠肝脏进行检测。结果:蒿甲醚组的存活率73.3%、磺胺嘧啶钠组的存活率为60%,两种药物治疗效果差异具有统计学意义(P<0.05),蒿甲醚组治疗效果优于磺胺嘧啶钠组。结论:本研究初步探讨了蒿甲醚治疗弓形虫的理论机制,实验结果表明蒿甲醚对治疗急性弓形虫感染有一定的疗效,为蒿甲醚用于临床治疗弓形虫病提供了依据。
OBJECTIVE: Toxoplasma gondii as a specialized intracellular parasite medical protozoa has attracted extensive attention in maternal and child health care, and studies the role of artemether in the treatment of Toxoplasma gondii infection, providing new clinical toxoplasmosis infection in pregnant women, especially pregnant women. Treatment strategy. METHODS: A mouse model of Toxoplasma gondii infection was established. The mice infected with Toxoplasma gondii were divided into two groups and treated with artemether and sulfadiazine sodium, respectively. The survival of mice in each group was observed, and the livers of mice were detected by PCR. Results: The survival rate of artemether group was 73.3%, and the survival rate of sulfadiazine group was 60%. The difference between the two drugs was statistically significant (P<0.05). The effect of artemether group was better than that of sulfadiazine sodium. group. Conclusion: This study preliminarily explored the theoretical mechanism of artemether treatment of Toxoplasma gondii. The experimental results show that artemether has a certain curative effect on the treatment of acute Toxoplasma gondii infection, and provides a basis for the clinical treatment of toxoplasmosis in artemether.