论文部分内容阅读
作者因头痛服用止痛剂,意外地得使其本人过敏性鼻炎症状减轻。该药中含有乙酰氨基酚、柳酸铵、阿斯匹林和咖啡因,估计是咖啡因之作用,认为黄嘌呤(Xanthine),包括咖啡因,具有抑制环核苷酸磷酸二酯酶(cyclic nucleotide phosphodiesterase)的作用,从而增加了细胞内环一磷酸腺苷(cAMP)的水平,这就使组织胺释放减少,也使肥大细胞脱颗粒作用降低。为验证咖啡因的这种作用,作者进行自我双盲试验:即用140mg咖啡因置于胶囊内,共8个,另有8个胶囊为安慰剂,每晨在通常醒前的一小时被唤醒任意服用一种胶囊,连续16天,对照两种胶囊服用后的效果。结果是喷嚏次数和不
The author takes painkillers for headaches and unexpectedly alleviates the symptoms of his allergic rhinitis. The drug contains acetaminophen, ammonium salicylate, aspirin, and caffeine, which is estimated to be caffeine. It is believed that Xanthine, including caffeine, has an inhibitory effect on cyclic nucleotide phosphodiesterase (cyclic nucleotide phosphodiesterase, thereby increasing the level of intracellular cyclic adenosine monophosphate (cAMP), which leads to a decrease in histamine release and also a reduction of mast cell degranulation. To verify this effect of caffeine, the authors conducted a self-double-blind trial of caffeine in 140 mg capsules in a total of 8 capsules and 8 capsules as placebo, awakening one morning before the usual waking hour Take one capsule at any time for 16 consecutive days and compare the effect of two capsules. The result is the number of sneezes and no