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乙酰胆碱 M受体 (M受体 )是一类位于细胞膜上具有重要功能的糖蛋白 ,药理学上将其分为 M1 、M2和 M3三大类 ,根据氨基酸组成 ,又可分 m1 、m2 、m3、m4和 m5 五个亚型。有机磷化合物中毒后可导致机体乙酰胆碱蓄积 ,持续作用于 M受体 ,致使受体密度和亲和力发生改变 ,进而通过 M受体偶联的肌醇磷脂、环核苷酸及 Ca2 + 等第二信使系统 ,引发一系列的病理生理反应。众多研究表明 ,有机磷化合物种类、中毒途径、中毒时间及剂量的大小的不同 ,对机体 M受体及其信号传导的影响不完全相同 ,急性中毒可使 M受体亲和力下降 ,慢性或亚急性中毒导致 M受体下调 ,二者均导致信号系统的异常增强 ,从而发挥其毒性作用
Acetylcholine M receptor (M receptor) is a type of glycoprotein which is located on the cell membrane and has an important function. It is divided into M1, M2 and M3 pharmacologically. According to the amino acid composition, it can be divided into m1, m2 and m3 , M4 and m5 five subtypes. Organophosphorus poisoning can lead to the accumulation of acetylcholine in the body and continue to act on the M receptor, causing the density and affinity of the receptor to change, which in turn is mediated by M receptor-coupled inositol phosphatids, cyclic nucleotides and second messengers such as Ca2 + System, triggering a series of pathophysiological responses. Numerous studies have shown that different types of organophosphorus compounds, poisoning pathways, poisoning time and the size of the dose, the impact on the M receptor and its signal transduction is not exactly the same, acute poisoning M receptor affinity can be reduced, chronic or subacute Toxicity leads to a down-regulation of M receptors, both of which lead to an abnormal increase of the signaling system, thereby exerting its toxic effect