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将２７只３月龄ＳＤ雌大白鼠随机分为基础对照组（Ａ）、年龄对照组（Ｂ）、去卵巢组（Ｃ）和去卵巢加己烯雌酚（ＤＥＳ）治疗组（Ｄ）。Ｂ组和Ｃ组用生理盐水５ｍｌ·ｋｇ－１／ｄ．ｉｇ，Ｄ组用浓度为４．５ｍｇ／Ｌ的己烯雌酚按５ｍｌ·ｋｇ－１／ｄ．ｉｇ，每周６次。１２周后，对各组大鼠胫骨中段不脱钙骨片进行骨计量学分析。去卵巢大鼠由于骨吸收大于骨形成，密质骨变薄，骨髓腔扩大，出现高转换型骨质疏松，己烯雌酚能明显抑制去卵巢后的骨高转换，保持密质骨厚度，维持骨量的正常。
Thirty-seven 3-month-old SD female rats were randomly divided into basic control group (A), age control group (B), ovariectomized group (C) and ovariectomized female rats treated with DES (D). Group B and C were treated with saline 5ml · kg-1 / d. ig, D group with a concentration of 4.5mg / L of diethylstilbestrol by 5ml · kg-1 / d. ig, 6 times a week. Twelve weeks later, bone biomechanics analysis was performed on the non-decalcified bone fragments of the middle tibia of rats in each group. In ovariectomized rats, bone resorption is greater than bone formation, dense bone is thinned, bone marrow cavity is enlarged and high conversion osteoporosis occurs. Diethylstilbestrol can significantly inhibit the bone turnover after ovariectomy, maintain the density of bone and maintain the bone mass Normal.