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迄今,滤过手术仍然是比较普遍采用的治疗青光眼的方法之一。尽管在手术方法上已有了许多改进,但仍有许多失败的病例,尤其是远期效果不能完全令人满意,对一些继发性青光眼及新生血管性青光眼的效果更差。近年来,有人主张除研究改进手术方法以外,还要研究如何利用药物来预防滤过泡过分疤痕化,以提高手术成功率。例如现在普遍采用的手术前后口服皮质类固醇,结膜下注射强的松,以及最近由Gressel(1984)等提出的结膜下注射氟尿嘧啶等。现将有关这一方面的资料加以复习并综述如下。
To date, filtration surgery is still one of the more commonly used methods of treating glaucoma. Although many improvements have been made in surgical procedures, there are still many failed cases. In particular, the long-term effects are not completely satisfactory, and the effect is worse for some secondary glaucoma and neovascular glaucoma. In recent years, some people advocate that in addition to studying and improving surgical methods, it is necessary to study how to use drugs to prevent over scarring of filtration bilirubes in order to improve the success rate of surgery. For example, pre-and post-operative oral corticosteroids are commonly used today, prednisone is injected subconjunctivally, and subconjunctival injection of fluorouracil and the like recently proposed by Gressel et al. The relevant information in this regard is now reviewed and summarized below.