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目的 观察吉西他滨联合顺铂治疗蒽环类耐药的晚期乳腺癌的疗效及毒副反应。方法 采用吉西他滨 10 0 0mg/m2 ,第 1天、第 8天静脉滴注 ;顺铂 2 0mg/m2 ,第 2～ 5天静脉滴注。 3～ 4周为一疗程。所有病例均化疗 2疗程。结果 30例中完全缓解 3例 ,部分缓解 15例 ,有效率 6 0 % (18/ 30 )。主要毒副反应为血小板减少。结论 吉西他滨联合顺铂治疗蒽环类耐药晚期乳腺癌疗效高 ,毒副反应可耐受
Objective To observe the efficacy and side effects of gemcitabine combined with cisplatin in the treatment of anthracycline-resistant advanced breast cancer. Methods Gemcitabine 10 0mg / m2, the first day, the eighth day intravenous drip; cisplatin 20mg / m2, 2 to 5 days intravenous drip. 3 to 4 weeks for a course of treatment. All cases were chemotherapy 2 courses. Results The complete remission in 30 cases in 3 cases, partial remission in 15 cases, the effective rate 60% (18/30). The main side effects of thrombocytopenia. Conclusion Gemcitabine combined with cisplatin in the treatment of advanced anthracycline-resistant breast cancer has high efficacy and tolerability