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目的 观察经阴道子宫切除术 (VH)与开腹子宫切除术 (LH)手术对患者血清白细胞介素 6和C 反应蛋白的影响。方法 将 6 6例符合经阴道子宫切除手术指征的患者随机分为经阴道子宫切除组 32例 ,开腹子宫切除组 34例。ELISH双抗体夹心法及散射比浊法检测手术前、术后 2 4h和 4 8h血清白细胞介素 6(IL 6 )和C 反应蛋白 (CRP)的变化。结果 开腹子宫切除组术后 2 4h、4 8h的血清IL 6和CRP水平均明显高于术前 (P <0 0 1)。结论 开腹子宫切除术后IL 6和C 反应蛋白水平均升高 ,与组织创伤有关
Objective To observe the effects of vaginal hysterectomy (VH) and open hysterectomy (LH) on serum interleukin-6 and C-reactive protein in patients. Methods Sixty-six patients who underwent transvaginal hysterectomy were randomly divided into transvaginal hysterectomy group (n = 32) and open hysterectomy group (n = 34). ELISH double antibody sandwich method and nephelometry were used to detect the changes of serum interleukin 6 (IL 6) and C-reactive protein (CRP) at 24 h and 48 h after operation. Results The levels of IL 6 and CRP in serum of 24 h and 48 h after open hysterectomy were significantly higher than those before operation (P <0.01). Conclusions The levels of IL-6 and C-reactive protein increased after open hysterectomy and are associated with tissue trauma