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Dear Editor,In the eukaryotic cell,the nuclear envelope separates genomic DNA from the rest of the cell,but ensures a molecular communication between the nucleus and the cytoplasm through the nuclear pore complexes (NPCs).Nuclear transport of macromolecules is an energy-dependent process,exemplified by the classical nuclear import pathway.In the cytoplasm,proteins containing classical nuclear localization signals (cNLSs) are recognized by a hetero-dimeric transport receptor (importin-α (Impα):importin-β (Impβ) complex).