论文部分内容阅读
【目的】观察喘可治注射液足三里穴位注射联合化疗对Ⅲ、Ⅳ期老年非小细胞肺癌(NSCLC)患者生存质量的影响。【方法】采用前瞻性、随机、对照的临床研究方法 ,将62例老年NSCLC病例随机分为试验组32例(喘可治注射液足三里穴位注射+中医辨证论治+化疗)和对照组30例(中医辨证论治+化疗)。采用世界卫生组织(WHO)生存质量老年模块量表(WHOQOL-OLD)、肺癌治疗功能评价表(FACT-L V4.0)及简明疲劳量表(BFI)对治疗前后的生存质量变化进行评价分析。【结果】(1)在WHOQOL-OLD评价中,试验组治疗后在感觉能力、自主、过去现在和将来行为、社会参与等4个模块及总分均有显著改善(P<0.01),而对照组仅在社会参与模块及总分有改善(P<0.01),试验组的自主模块评分差值较对照组高(P<0.01)。(2)在FACT-L V4.0评价中,试验组治疗后在生理状况、情感状况、功能状况、附加关注等4个领域及总分均有显著改善(P<0.01),而对照组仅在情感状况、附加关注领域及总分有显著改善(P<0.01),试验组在生理状况、功能状况及附加关注等3个领域的评分差值较对照组高(P<0.01)。(3)在BFI评价中,2组均能改善老年NSCLC患者的疲劳程度及疲劳影响情况(P<0.01),且试验组的改善效果优于对照组(P<0.05)。【结论】喘可治注射液足三里穴位注射能够改善老年NSCLC化疗患者在感觉能力、自主、过去现在和将来行为、社会参与等模块,以及生理状况、功能状况、附加关注等领域的生存质量,并能改善患者疲劳程度及疲劳影响情况。
【Objective】 To observe the effect of Chuanzhusi injection Zusanli point combined with chemotherapy on the quality of life of patients with stage Ⅲ, Ⅳ non-small cell lung cancer (NSCLC). 【Methods】 Sixty-two elderly patients with NSCLC were randomly divided into experimental group (32 cases) (treated with Zusanli Injection Zusanli Point injection + TCM Syndrome Differentiation and Chemotherapy) and control group (n = 30), with a prospective, randomized and controlled clinical study TCM syndrome differentiation treatment + chemotherapy). The changes of the quality of life before and after treatment were evaluated by WHOQOL-OLD, FACT-L V4.0 and BFI . 【Results】 (1) In the WHOQOL-OLD evaluation, there were significant improvements (P <0.01) in the four modules of QOL-OLD test, including sensory ability, autonomy, past present and future behavior and social participation Group only improved in social participation module and total score (P <0.01). The difference of independent module score in experimental group was higher than that in control group (P <0.01). (2) In the evaluation of FACT-L V4.0, the experimental group had significant improvement (P <0.01) in the four fields of physiological status, emotional status, functional status and additional attention after treatment (P <0.01) There were significant differences (P <0.01) in the emotional status, additional areas of attention and total scores (P <0.01). The scores of the test group were higher than those in the control group in physiological status, functional status and additional attention (P <0.01). (3) In the BFI evaluation, both groups can improve the fatigue and fatigue of elderly patients with NSCLC (P <0.01), and the improvement effect of the experimental group is better than that of the control group (P <0.05). 【Conclusion】 Chuan San Zhi Injection can improve the quality of life, improve the quality of life of senile NSCLC patients in sensory ability, autonomic, past and present and future behavior, social participation and other modules, as well as physiological status, functional status, And can improve patient fatigue and fatigue effects.